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Gene : IL4R Homo sapiens

Name  ? interleukin 4 receptor Cytological Location  16p12.1
Brief Description  interleukin 4 receptor
description  This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
  • synonyms:
  • X52425,
  • IL-4RA,
  • CD124,
  • HGNC:6015,
  • IL4R,
  • CD124,
  • uc002don.5,
  • OTTHUMG00000097015,
  • IL4RA,
  • NM_000418,
  • interleukin 13 receptor
  • identifiers:
  • 3566,
  • ENSG00000077238,
  • IL4R

Genome feature

Region: gene ? Length: 51111  
Location: 16:27313668-27364778 Cyto location: 16p12.1

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2 Diseases

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568 SN Ps

5 Cross References

20 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results