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Gene : IDO1 Homo sapiens

Name  ? indoleamine 2,3-dioxygenase 1 Cytological Location  8p11.21
Brief Description  indoleamine 2,3-dioxygenase 1
Description  This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
  • synonyms:
  • IDO1,
  • HGNC:6059,
  • uc064mfz.1,
  • IDO-1,
  • OTTHUMG00000164057,
  • IDO,
  • INDO,
  • M34455,
  • indoleamine-pyrrole 2,3 dioxygenase,
  • INDO,
  • NM_002164,
  • IDO
  • identifiers:
  • 3620,
  • ENSG00000131203,
  • IDO1

Genome feature

Region: gene ? Length: 14900  
Location: 8:39913891-39928790 Cyto location: 8p11.21


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928 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results