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Gene : INSIG1 Homo sapiens

Name  ? insulin induced gene 1 Cytological Location  7q36.3
Brief Description  insulin induced gene 1
Description  This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
  • synonyms:
  • OTTHUMG00000151330,
  • HGNC:6083,
  • NM_198336,
  • CL6,
  • MGC1405,
  • uc003wly.3,
  • INSIG-1 membrane protein,
  • INSIG1,
  • CL-6
  • identifiers:
  • 3638,
  • ENSG00000186480,
  • INSIG1

Genome feature

Region: gene ? Length: 12464  
Location: 7:155297772-155310235 Cyto location: 7q36.3


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Proteins

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SNPs

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Disease

0 Diseases

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Expression

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Other

98 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results