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Gene : ITGAL Homo sapiens

Name  ? integrin subunit alpha L Cytological Location  16p11.2
Brief Description  integrin subunit alpha L
Description  ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CD11A,
  • ITGAL,
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide),
  • LFA-1,
  • lymphocyte function-associated antigen 1, alpha polypeptide,
  • NM_001114380,
  • OTTHUMG00000176964,
  • LFA1A,
  • uc002dyi.5,
  • HGNC:6148,
  • CD11A,
  • LFA-1,
  • antigen CD11A (p180)
  • identifiers:
  • 3683,
  • ENSG00000005844,
  • ITGAL

Genome feature

Region: gene ? Length: 50503  
Location: 16:30472683-30523185 Cyto location: 16p11.2


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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

103 SN Ps

5 Cross References

18 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results