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Gene : CENPS Homo sapiens

Name  ? centromere protein S Cytological Location  1p36.22
Brief Description  centromere protein S
Description  This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2010]
  • synonyms:
  • uc001are.4,
  • CENP-S,
  • HGNC:23163,
  • FAAP16,
  • apoptosis-inducing, TAF9-like domain 1,
  • FANCM associated histone fold protein 1,
  • MHF1,
  • OTTHUMG00000059085,
  • CENP-S,
  • APITD1,
  • CENPS,
  • BC029430,
  • APITD1,
  • FAAP16,
  • NM_199294,
  • MHF1
  • identifiers:
  • 378708,
  • ENSG00000175279,

Genome feature

Region: gene ? Length: 12376  
Location: 1:10430433-10442808 Cyto location: 1p36.22

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0 Diseases

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3753 SN Ps

4 Cross References

13 Data Sets

1 Homologues

0 Located Features

97 Rna Seq Results