help  | about  | cite  | software

Gene : FLG2 Homo sapiens

Name  ? filaggrin family member 2 Cytological Location  1q21.3
Brief Description  filaggrin family member 2
Description  The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
  • synonyms:
  • HGNC:33276,
  • NM_001014342,
  • IFPS,
  • PSS6,
  • OTTHUMG00000012245,
  • FLG2,
  • IFPS,
  • AY827490,
  • uc001ezw.5
  • identifiers:
  • 388698,
  • ENSG00000143520,
  • FLG2

Genome feature

Region: gene ? Length: 11294  
Location: 1:152348735-152360028 reverse strand Cyto location: 1q21.3


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

530 SN Ps

5 Cross References

17 Data Sets

1 Homologues

0 Located Features

97 Rna Seq Results