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Gene : FLG2 Homo sapiens

Name  ? filaggrin family member 2 Cytological Location  1q21.3
Brief Description  filaggrin family member 2
Description  The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
  • synonyms:
  • HGNC:33276,
  • NM_001014342,
  • IFPS,
  • PSS6,
  • OTTHUMG00000012245,
  • FLG2,
  • IFPS,
  • AY827490,
  • uc001ezw.5
  • identifiers:
  • 388698,
  • ENSG00000143520,
  • FLG2

Genome feature

Region: gene ? Length: 11294  
Location: 1:152348735-152360028 reverse strand Cyto location: 1q21.3

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



530 SN Ps

5 Cross References

17 Data Sets

1 Homologues

0 Located Features

97 Rna Seq Results