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Gene : BCAR4 Homo sapiens

Name  ? breast cancer anti-estrogen resistance 4 Cytological Location  16p13.13
Brief Description  breast cancer anti-estrogen resistance 4
Description  This gene produces a spliced long non-coding RNA (lncRNA) that has been implicated in breast cancer metastasis. It was originally identified in a screen for genes responsible for the development of resistance to anti-estrogens in breast cancer cells. It is thought that release of CCL21 enables this lncRNA to bind to the SNIP1 and PNUTS transcription factors, thereby activating a non-canonical GLI-dependent hedgehog signaling pathway that promotes cancer cell migration and invasion. A similar gene in cow expresses a protein in mature oocytes and preimplantation embryos. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2015]
  • synonyms:
  • BCAR4,
  • HGNC:22170,
  • uc059qxb.1,
  • breast cancer anti-estrogen resistance 4,
  • NR_024049,
  • OTTHUMG00000177469,
  • breast cancer anti-estrogen resistance 4 (non-protein coding)
  • identifiers:
  • 400500,
  • ENSG00000262117,
  • BCAR4

Genome feature

Region: gene ? Length: 9003  
Location: 16:11819830-11828832 reverse strand Cyto location: 16p13.13

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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0 Pathways

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4 Cross References

8 Data Sets

0 Homologues

0 Located Features

54 Rna Seq Results