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Gene : CD46 Homo sapiens

Name  ? CD46 molecule Cytological Location  1q32.2
Brief Description  CD46 molecule
Description  The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • synonyms:
  • TLX,
  • MIC10,
  • BC030594,
  • TRA2.10,
  • AHUS2,
  • antigen identified by monoclonal antibody TRA-2-10,
  • TRA2.10,
  • MCP,
  • NM_172361,
  • OTTHUMG00000036397,
  • TLX,
  • HGNC:6953,
  • MIC10,
  • CD46 antigen, complement regulatory protein,
  • MCP,
  • CD46,
  • uc001hgj.4,
  • CD46 molecule, complement regulatory protein,
  • MGC26544,
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • identifiers:
  • 4179,
  • ENSG00000117335,
  • CD46

Genome feature

Region: gene ? Length: 43479  
Location: 1:207752038-207795516 Cyto location: 1q32.2

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1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

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Gene Ontology

Gene --> GO terms.



3740 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results