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Gene : ASIP Homo sapiens

Name  ? agouti signaling protein Cytological Location  20q11.22
Brief Description  agouti signaling protein
Description  In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
  • synonyms:
  • agouti (mouse)-signaling protein,
  • nonagouti homolog (mouse),
  • OTTHUMG00000032289,
  • SHEP9,
  • AGTI,
  • NM_001385218,
  • ASP,
  • agouti signaling protein, nonagouti homolog (mouse),
  • AGTIL,
  • ASP,
  • AGSW,
  • HGNC:745,
  • AGTIL,
  • uc061wig.1,
  • ASIP
  • identifiers:
  • 434,
  • ENSG00000101440,
  • ASIP

Genome feature

Region: gene ? Length: 82852  
Location: 20:34186493-34269344 Cyto location: 20q11.22

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

3740 SNPs

4 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results