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Gene : ATF4 Homo sapiens
Name  ? activating transcription factor 4 Cytological Location  22q13.1
Brief Description  activating transcription factor 4
Description  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011]
  • synonyms:
  • TAXREB67,
  • TAXREB67,
  • D90209,
  • NM_001675,
  • uc021wpz.2,
  • HGNC:786,
  • CREB2,
  • tax-responsive enhancer element B67,
  • OTTHUMG00000151099,
  • ATF4,
  • TXREB,
  • CREB-2,
  • TXREB,
  • activating transcription factor 4 (tax-responsive enhancer element B67),
  • CREB-2
  • identifiers:
  • 468,
  • ENSG00000128272,
  • ATF4

Genome feature

Region: gene ? Length: 8193  
Location: 22:39514494-39522686 Cyto location: 22q13.1


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Lists
This Gene is in one list:
PL_BHF_UCL_cardiovascGenes (4103)

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Function

Gene Ontology Displayer

10 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

10 Pathways

3740 SN Ps

5 Cross References

15 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results





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