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Gene : ACLY Homo sapiens

Name  ? ATP citrate lyase Cytological Location  17q21.2
Brief Description  ATP citrate lyase
Description  ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
  • synonyms:
  • ATP citrate synthase,
  • ACL,
  • HGNC:115,
  • ATPCL,
  • OTTHUMG00000133507,
  • CLATP,
  • ACLY,
  • X64330,
  • CLATP,
  • ACL,
  • NM_001096,
  • ATPCL,
  • uc002hyg.4
  • identifiers:
  • 47,
  • ENSG00000131473,
  • ACLY

Genome feature

Region: gene ? Length: 63627  
Location: 17:41866916-41930542 reverse strand Cyto location: 17q21.2

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Gene -> HPO annotation (Human Phenotype Ontology)

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Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

18 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results