help  | about  | cite  | software

Gene : ATP2B4 Homo sapiens

Name  ? ATPase plasma membrane Ca2+ transporting 4 Cytological Location  1q32.1
Brief Description  ATPase plasma membrane Ca2 transporting 4
Description  The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
  • synonyms:
  • MXRA1,
  • ATP2B2,
  • PMCA4b,
  • PMCA4,
  • OTTHUMG00000035906,
  • PMCA4,
  • plasma membrane calcium-transporting ATPase 4,
  • uc001gzw.4,
  • ATP2B4,
  • matrix-remodelling associated 1,
  • MXRA1,
  • ATP2B2,
  • M25874,
  • NM_001001396,
  • HGNC:817,
  • ATPase, Ca++ transporting, plasma membrane 4,
  • PMCA4x
  • identifiers:
  • 493,
  • ENSG00000058668,
  • ATP2B4

Genome feature

Region: gene ? Length: 117250  
Location: 1:203626832-203744081 Cyto location: 1q32.1

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



315 SN Ps

5 Cross References

17 Data Sets

8 Homologues

0 Located Features

97 Rna Seq Results