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Gene : OAS1 Homo sapiens

Name  ? 2'-5'-oligoadenylate synthetase 1 Cytological Location  12q24.13
Brief Description  2'-5'-oligoadenylate synthetase 1
Description  This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, Feb 2016]
  • synonyms:
  • 2'-5'-oligoadenylate synthetase 1, 40/46kDa,
  • HGNC:8086,
  • OIASI,
  • IFI-4,
  • OTTHUMG00000169792,
  • OIASI,
  • OAS1,
  • OIAS,
  • 2',5'-oligoadenylate synthetase 1 (40-46 kD),
  • X04371,
  • NM_001032409,
  • IFI-4,
  • E18/E16,
  • 2'-5' oligoadenylate synthase 1,
  • OIAS,
  • uc001tuc.4
  • identifiers:
  • 4938,
  • ENSG00000089127,
  • OAS1

Genome feature

Region: gene ? Length: 26264  
Location: 12:112906956-112933219 Cyto location: 12q24.13

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3740 SN Ps

5 Cross References

16 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results