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Gene : GLRX2 Homo sapiens

Name  ? glutaredoxin 2 Cytological Location  1q31.2
Brief Description  glutaredoxin 2
Description  The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]
  • synonyms:
  • glutaredoxin (thioltransferase) 2,
  • GLRX2,
  • NM_016066,
  • GRX2,
  • bA101E13.1,
  • AF132495,
  • CGI-133,
  • GRX2,
  • uc001gta.3,
  • OTTHUMG00000035677,
  • HGNC:16065
  • identifiers:
  • 51022,
  • ENSG00000023572,
  • GLRX2

Genome feature

Region: gene ? Length: 9650  
Location: 1:193096465-193106114 reverse strand Cyto location: 1q31.2


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Proteins

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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

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Expression

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0 Pathways

3753 SN Ps

5 Cross References

16 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results