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Gene : DPH5 Homo sapiens

Name  ? diphthamide biosynthesis 5 Cytological Location  1p21.2
Brief Description  diphthamide biosynthesis 5
Description  This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • CGI-30,
  • HGNC:24270,
  • AD-018,
  • AF132964,
  • DPH5 homolog (S. cerevisiae),
  • DPH5,
  • CGI-30,
  • NM_015958,
  • HSPC143,
  • uc001dts.4,
  • OTTHUMG00000010829,
  • NPD015
  • identifiers:
  • 51611,
  • ENSG00000117543,
  • DPH5

Genome feature

Region: gene ? Length: 50589  
Location: 1:100975218-101025806 reverse strand Cyto location: 1p21.2


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

15 SN Ps

5 Cross References

16 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results