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Gene : GHRL Homo sapiens

Name  ? ghrelin and obestatin prepropeptide Cytological Location  3p25.3
Brief Description  ghrelin and obestatin prepropeptide
Description  This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
  • synonyms:
  • NM_016362,
  • AF296558,
  • uc021wsz.2,
  • ghrelin, growth hormone secretagogue receptor ligand,
  • MTLRP,
  • ghrelin,
  • obestatin,
  • HGNC:18129,
  • MTLRP,
  • GHRL,
  • prepro-appetite regulatory hormone,
  • OTTHUMG00000155360,
  • ghrelin/obestatin prepropeptide
  • identifiers:
  • 51738,
  • ENSG00000157017,
  • GHRL

Genome feature

Region: gene ? Length: 7282  
Location: 3:10285666-10292947 reverse strand Cyto location: 3p25.3

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1 Diseases

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3753 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results