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Gene : ERAP1 Homo sapiens

Name  ? endoplasmic reticulum aminopeptidase 1 Cytological Location  5q15
Brief Description  endoplasmic reticulum aminopeptidase 1
Description  The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
  • synonyms:
  • AB011097,
  • uc003kml.4,
  • HGNC:18173,
  • APPILS,
  • ERAAP1,
  • ARTS-1,
  • ALAP,
  • KIAA0525,
  • A-LAP,
  • PILSAP,
  • PILS-AP,
  • aminopeptidase regulator of TNFR1 shedding,
  • ARTS1,
  • OTTHUMG00000128721,
  • NM_016442,
  • PILS-AP,
  • ARTS-1,
  • ERAAP1,
  • ERAAP,
  • puromycin-insensitive leucyl-specific aminopeptidase,
  • ERAP1,
  • adipocyte-derived leucine aminopeptidase,
  • A-LAP
  • identifiers:
  • 51752,
  • ENSG00000164307,
  • ERAP1

Genome feature

Region: gene ? Length: 175711  
Location: 5:96760273-96935983 reverse strand Cyto location: 5q15


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

17 Data Sets

19 Homologues

0 Located Features

97 Rna Seq Results