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Gene : ATP8A2 Homo sapiens

Name  ? ATPase phospholipid transporting 8A2 Cytological Location  13q12.13
Brief Description  ATPase phospholipid transporting 8A2
Description  The protein encoded by this gene is a member of the P4 ATPase family of proteins, which are thought to be involved in a process called lipid flipping, whereby phospholipids are translocated inwards from the exoplasmic leaflet to the cytosolic leaflet of the cell membrane, which aids in generating and maintaining asymmetry in membrane lipids. This protein is predicted to contain an E1 E2 ATPase, a haloacid dehalogenase-like hydrolase (HAD) domain, and multiple transmembrane domains. Associations between this protein and cell cycle control protein 50A are important for translocation of phosphatidylserine across membranes. Mutations in this gene have been associated with a syndrome (CAMRQ4) characterized by cerebellar ataxia and cognitive disabilities. In addition, a translocation breakpoint within this gene was observed in an individual with neurological dysfunction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
  • synonyms:
  • ML-1,
  • IB,
  • ATPIB,
  • CAMRQ4,
  • ATP8A2,
  • AL137256,
  • ATP,
  • HGNC:13533,
  • ATPase, aminophospholipid transporter-like, class I, type 8A, member 2,
  • NM_016529,
  • ATPase, aminophospholipid transporter-like, Class I, type 8A, member 2,
  • uc001uqk.4,
  • ATPIB,
  • OTTHUMG00000016611,
  • ATPase, aminophospholipid transporter, class I, type 8A, member 2,
  • ML-1
  • identifiers:
  • 51761,
  • ENSG00000132932,
  • ATP8A2

Genome feature

Region: gene ? Length: 653878  
Location: 13:25371974-26025851 Cyto location: 13q12.13


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Disease

1 Diseases

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3756 SN Ps

5 Cross References

19 Data Sets

16 Homologues

0 Located Features

97 Rna Seq Results