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Gene : ATP6V0A1 Homo sapiens

Name  ? ATPase H+ transporting V0 subunit a1 Cytological Location  17q21.2
Brief Description  ATPase H transporting V0 subunit a1
Description  This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • uc002hzs.4,
  • Vph1,
  • Stv1,
  • ATP6N1A,
  • OTTHUMG00000180238,
  • VPP1,
  • Vph1,
  • ATPase, H+ transporting, lysosomal V0 subunit a isoform 1,
  • NM_001130020,
  • ATP6N1,
  • ATP6N1,
  • ATP6V0A1,
  • HGNC:865,
  • ATPase, H+ transporting, lysosomal V0 subunit A1,
  • ATPase, H+ transporting, lysosomal V0 subunit a1,
  • ATP6N1A,
  • a1,
  • VPP1,
  • Stv1,
  • U73006,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD),
  • a1
  • identifiers:
  • 535,
  • ENSG00000033627,
  • ATP6V0A1

Genome feature

Region: gene ? Length: 63706  
Location: 17:42458874-42522579 Cyto location: 17q21.2

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981 SN Ps

5 Cross References

17 Data Sets

15 Homologues

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97 Rna Seq Results