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Gene : FXYD5 Homo sapiens

Name  ? FXYD domain containing ion transport regulator 5 Cytological Location  19q13.12
Brief Description  FXYD domain containing ion transport regulator 5
Description  This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
  • synonyms:
  • RIC,
  • OTTHUMG00000048092,
  • NM_014164,
  • OIT2,
  • KCT1,
  • FXYD domain-containing ion transport regulator 5,
  • dysadherin,
  • uc002nyg.3,
  • AF161462,
  • PRO6241,
  • IWU1,
  • DYSAD,
  • HSPC113,
  • OIT2,
  • FXYD5,
  • HGNC:4029
  • identifiers:
  • 53827,
  • ENSG00000089327,
  • FXYD5

Genome feature

Region: gene ? Length: 15147  
Location: 19:35154735-35169881 Cyto location: 19q13.12


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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Proteins

Gene --> Proteins.

SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

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Expression

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Other

0 Pathways

3753 SN Ps

5 Cross References

16 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results