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Gene : BRWD1 Homo sapiens

Name  ? bromodomain and WD repeat domain containing 1 Cytological Location  21q22.2
Brief Description  bromodomain and WD repeat domain containing 1
Description  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
  • synonyms:
  • FLJ11315,
  • C21orf107,
  • WDR9,
  • DCAF19,
  • HGNC:12760,
  • WRD9,
  • WD repeat domain 9,
  • OTTHUMG00000066030,
  • WDR9,
  • DCAF19,
  • chromosome 21 open reading frame 107,
  • C21orf107,
  • N143,
  • NM_033656,
  • uc002yxk.3,
  • N143,
  • AJ002572,
  • BRWD1
  • identifiers:
  • 54014,
  • ENSG00000185658,
  • BRWD1

Genome feature

Region: gene ? Length: 137420  
Location: 21:39184176-39321595 reverse strand Cyto location: 21q22.2

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



898 SN Ps

5 Cross References

17 Data Sets

4 Homologues

0 Located Features

97 Rna Seq Results