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Gene : POLE Homo sapiens

Name  ? DNA polymerase epsilon, catalytic subunit Cytological Location  12q24.33
Brief Description  DNA polymerase epsilon, catalytic subunit
Description  This gene encodes the catalytic subunit of DNA polymerase epsilon. The enzyme is involved in DNA repair and chromosomal DNA replication. Mutations in this gene have been associated with colorectal cancer 12 and facial dysmorphism, immunodeficiency, livedo, and short stature. [provided by RefSeq, Sep 2013]
  • synonyms:
  • POLE1,
  • FILS,
  • NM_006231,
  • uc001uks.3,
  • POLE1,
  • polymerase (DNA) epsilon, catalytic subunit,
  • polymerase (DNA directed), epsilon,
  • HGNC:9177,
  • OTTHUMG00000168045,
  • CRCS12,
  • POLE,
  • DNA polymerase epsilon catalytic subunit A
  • identifiers:
  • 5426,
  • ENSG00000177084,
  • POLE

Genome feature

Region: gene ? Length: 63762  
Location: 12:132623758-132687519 reverse strand Cyto location: 12q24.33

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

19 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results