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Gene : POR Homo sapiens

Name  ? cytochrome p450 oxidoreductase Cytological Location  7q11.23
Brief Description  cytochrome p450 oxidoreductase
Description  This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]
  • synonyms:
  • uc003udy.4,
  • OTTHUMG00000130413,
  • P450 (cytochrome) oxidoreductase,
  • P450R,
  • HGNC:9208,
  • AF258341,
  • CYPOR,
  • CPR,
  • FLJ26468,
  • POR,
  • NADPH--hemoprotein reductase,
  • CYPOR,
  • NM_000941
  • identifiers:
  • 5447,
  • ENSG00000127948,
  • POR

Genome feature

Region: gene ? Length: 71701  
Location: 7:75915155-75986855 Cyto location: 7q11.23

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3740 SN Ps

5 Cross References

19 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results