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Gene : ATR Homo sapiens

Name  ? ATR serine/threonine kinase Cytological Location  3q23
Brief Description  ATR serine/threonine kinase
Description  The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
  • synonyms:
  • MEC1, mitosis entry checkpoint 1, homolog (S. cerevisiae),
  • MEC1,
  • U76308,
  • ATR,
  • SCKL,
  • NM_001184,
  • FRP1,
  • FRP1,
  • SCKL1,
  • SCKL1,
  • MEC1,
  • HGNC:882,
  • uc003eux.5,
  • ataxia telangiectasia and Rad3 related,
  • SCKL,
  • FCTCS,
  • OTTHUMG00000159234
  • identifiers:
  • 545,
  • ENSG00000175054,
  • ATR

Genome feature

Region: gene ? Length: 129559  
Location: 3:142449235-142578793 reverse strand Cyto location: 3q23

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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

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3756 SN Ps

5 Cross References

19 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results