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Gene : MAGEL2 Homo sapiens

Name  ? MAGE family member L2 Cytological Location  15q11.2
Brief Description  MAGE family member L2
description  Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]
  • synonyms:
  • uc001ywj.5,
  • AJ243531,
  • MAGEL2,
  • melanoma antigen family L2,
  • PWLS,
  • NM_019066,
  • nM15,
  • NDNL1,
  • HGNC:6814,
  • OTTHUMG00000167582,
  • MAGE-like 2,
  • nM15,
  • NDNL1
  • identifiers:
  • 54551,
  • ENSG00000254585,
  • MAGEL2

Genome feature

Region: gene ? Length: 4319  
Location: 15:23643549-23647867 reverse strand Cyto location: 15q11.2

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

86 SN Ps

5 Cross References

16 Data Sets

40 Homologues

0 Located Features

97 Rna Seq Results