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Gene : NKX1-1 Homo sapiens

Name  ? NK1 homeobox 1 Cytological Location  4p16.3
Brief Description  NK1 homeobox 1
description  This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]
  • synonyms:
  • X76978,
  • SAX2,
  • OTTHUMG00000160165,
  • HSPX153,
  • SAX2,
  • uc062ulo.1,
  • HGNC:24975,
  • NKX-1.1,
  • NKX1-1,
  • NK1 transcription factor related, locus 1 (Drosophila),
  • NM_001290079,
  • HSPX153
  • identifiers:
  • 54729,
  • ENSG00000235608,
  • NKX1-1

Genome feature

Region: gene ? Length: 3511  
Location: 4:1402932-1406442 reverse strand Cyto location: 4p16.3

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Orthologues


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

0 SN Ps

5 Cross References

11 Data Sets

20 Homologues

0 Located Features

97 Rna Seq Results