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Gene : AUH Homo sapiens

Name  ? AU RNA binding methylglutaconyl-CoA hydratase Cytological Location  9q22.31
Brief Description  AU RNA binding methylglutaconyl-CoA hydratase
Description  This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • synonyms:
  • AUH,
  • AU RNA binding protein/enoyl-CoA hydratase,
  • uc004arf.5,
  • AU RNA binding protein/enoyl-Coenzyme A hydratase,
  • OTTHUMG00000020207,
  • AU RNA-binding protein/enoyl-Coenzyme A hydratase,
  • NM_001306190,
  • X79888,
  • HGNC:890
  • identifiers:
  • 549,
  • ENSG00000148090,
  • AUH

Genome feature

Region: gene ? Length: 148155  
Location: 9:91213815-91361969 reverse strand Cyto location: 9q22.31


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1 Diseases

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281 SN Ps

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97 Rna Seq Results