help  | about  | cite  | software

Gene : AUH Homo sapiens

Name  ? AU RNA binding methylglutaconyl-CoA hydratase Cytological Location  9q22.31
Brief Description  AU RNA binding methylglutaconyl-CoA hydratase
Description  This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • synonyms:
  • AUH,
  • AU RNA binding protein/enoyl-CoA hydratase,
  • uc004arf.5,
  • AU RNA binding protein/enoyl-Coenzyme A hydratase,
  • OTTHUMG00000020207,
  • AU RNA-binding protein/enoyl-Coenzyme A hydratase,
  • NM_001306190,
  • X79888,
  • HGNC:890
  • identifiers:
  • 549,
  • ENSG00000148090,
  • AUH

Genome feature

Region: gene ? Length: 148155  
Location: 9:91213815-91361969 reverse strand Cyto location: 9q22.31

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer

Gene --> Orthologues


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



281 SN Ps

5 Cross References

20 Data Sets

9 Homologues

0 Located Features

97 Rna Seq Results