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Gene : AUP1 Homo sapiens

Name  ? AUP1 lipid droplet regulating VLDL assembly factor Cytological Location  2p13.1
Brief Description  AUP1 lipid droplet regulating VLDL assembly factor
Description  The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
  • synonyms:
  • HGNC:891,
  • ancient ubiquitous protein 1,
  • OTTHUMG00000129964,
  • AUP1,
  • uc002smf.4,
  • NM_181575
  • identifiers:
  • 550,
  • ENSG00000115307,
  • AUP1

Genome feature

Region: gene ? Length: 3055  
Location: 2:74526652-74529706 reverse strand Cyto location: 2p13.1


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Disease

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0 Pathways

613 SN Ps

5 Cross References

15 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results