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Gene : CCDC88A Homo sapiens

Name  ? coiled-coil domain containing 88A Cytological Location  2p16.1
Brief Description  coiled-coil domain containing 88A
Description  This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
  • synonyms:
  • HkRP1,
  • PEHOL,
  • GIV,
  • HkRP1,
  • girders of actin filaments,
  • KIAA1212,
  • NM_017571,
  • OTTHUMG00000151915,
  • AB033038,
  • GRDN,
  • girdin,
  • PEHO,
  • uc010yoz.2,
  • FLJ10392,
  • AF112218,
  • APE,
  • GRDN,
  • GIV,
  • CCDC88A,
  • Galpha-interacting vesicle-associated protein,
  • APE,
  • KIAA1212,
  • Akt-phosphorylation enhancer,
  • HGNC:25523
  • identifiers:
  • 55704,
  • ENSG00000115355,
  • CCDC88A

Genome feature

Region: gene ? Length: 132040  
Location: 2:55287817-55419856 reverse strand Cyto location: 2p16.1

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Proteins.


Gene Report --> GWAS hit


1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



0 Pathways

3740 SN Ps

5 Cross References

19 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results