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Gene : DOK5 Homo sapiens

Name  ? docking protein 5 Cytological Location  20q13.2
Brief Description  docking protein 5
Description  The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
  • synonyms:
  • IRS6,
  • HGNC:16173,
  • AF132732,
  • chromosome 20 open reading frame 180,
  • dJ805C22.1,
  • C20orf180,
  • C20orf180,
  • IRS-6,
  • NM_001294161,
  • DOK5,
  • uc002xwy.4,
  • OTTHUMG00000032778
  • identifiers:
  • 55816,
  • ENSG00000101134,
  • DOK5

Genome feature

Region: gene ? Length: 175579  
Location: 20:54475593-54651171 Cyto location: 20q13.2

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



681 SN Ps

5 Cross References

16 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results