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Gene : CAND1 Homo sapiens

Name  ? cullin associated and neddylation dissociated 1 Cytological Location  12q14.3-q15
Brief Description  cullin associated and neddylation dissociated 1
Description  This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]
  • synonyms:
  • uc001stn.3,
  • OTTHUMG00000169060,
  • CAND1,
  • HGNC:30688,
  • cullin-associated and neddylation-dissociated 1,
  • TIP120,
  • DKFZp434M1414,
  • KIAA0829,
  • TBP interacting protein,
  • TIP120,
  • TIP120A,
  • NM_018448,
  • TIP120A
  • identifiers:
  • 55832,
  • ENSG00000111530,
  • CAND1

Genome feature

Region: gene ? Length: 50596  
Location: 12:67269358-67319953 Cyto location: 12q14.3-q15

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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3740 SNPs

5 Cross References

17 Data Sets

5 Homologues

0 Located Features

97 Rna Seq Results