help  | about  | cite  | software

Gene : HDAC8 Homo sapiens

Name  ? histone deacetylase 8 Cytological Location  Xq13.1
Brief Description  histone deacetylase 8
Description  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
  • synonyms:
  • OTTHUMG00000021814,
  • MRXS6,
  • CDLS5,
  • NM_018486,
  • HGNC:13315,
  • CDA07,
  • MRXS6,
  • AF230097,
  • RPD3,
  • HD8,
  • WTS,
  • RPD3,
  • KDAC8,
  • HDACL1,
  • WTS,
  • HDAC8,
  • uc004eau.3,
  • HDACL1,
  • KDAC8,
  • Wilson-Turner X-linked mental retardation syndrome,
  • histone deacetylase-like 1
  • identifiers:
  • 55869,
  • ENSG00000147099,
  • HDAC8

Genome feature

Region: gene ? Length: 243588  
Location: X:72329516-72573103 reverse strand Cyto location: Xq13.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

41 SN Ps

5 Cross References

17 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results