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Gene : BAIAP2L1 Homo sapiens

Name  ? BAR/IMD domain containing adaptor protein 2 like 1 Cytological Location  7q21.3-q22.1
Brief Description  BAR/IMD domain containing adaptor protein 2 like 1
Description  This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]
  • synonyms:
  • insulin receptor tyrosine kinase substrate,
  • NM_018842,
  • IRTKS,
  • OTTHUMG00000165117,
  • uc003upj.4,
  • IRTKS,
  • HGNC:21649,
  • AF119666,
  • BAI1 associated protein 2 like 1,
  • BAIAP2L1
  • identifiers:
  • 55971,
  • ENSG00000006453,
  • BAIAP2L1

Genome feature

Region: gene ? Length: 109441  
Location: 7:98291650-98401090 reverse strand Cyto location: 7q21.3-q22.1


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Disease

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Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Mouse Gene --> Allele [Phenotype]

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0 Pathways

3756 SN Ps

5 Cross References

16 Data Sets

7 Homologues

0 Located Features

97 Rna Seq Results