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Gene : EIF2AK2 Homo sapiens

Name  ? eukaryotic translation initiation factor 2 alpha kinase 2 Cytological Location  2p22.2
Brief Description  eukaryotic translation initiation factor 2 alpha kinase 2
Description  The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • synonyms:
  • PKR,
  • OTTHUMG00000100962,
  • PRKR,
  • HGNC:9437,
  • protein kinase, interferon-inducible double stranded RNA dependent,
  • PKR,
  • NM_002759,
  • PRKR,
  • EIF2AK1,
  • PPP1R83,
  • PPP1R83,
  • EIF2AK2,
  • EIF2AK1,
  • BC057805,
  • uc010fac.4,
  • protein phosphatase 1, regulatory subunit 83
  • identifiers:
  • 5610,
  • ENSG00000055332,
  • EIF2AK2

Genome feature

Region: gene ? Length: 57856  
Location: 2:37099210-37157065 reverse strand Cyto location: 2p22.2

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3753 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results