help  | about  | cite  | software

Gene : EIF2AK2 Homo sapiens

Name  ? eukaryotic translation initiation factor 2 alpha kinase 2 Cytological Location  2p22.2
Brief Description  eukaryotic translation initiation factor 2 alpha kinase 2
Description  The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
  • synonyms:
  • PKR,
  • OTTHUMG00000100962,
  • PRKR,
  • HGNC:9437,
  • protein kinase, interferon-inducible double stranded RNA dependent,
  • PKR,
  • NM_002759,
  • PRKR,
  • EIF2AK1,
  • PPP1R83,
  • PPP1R83,
  • EIF2AK2,
  • EIF2AK1,
  • BC057805,
  • uc010fac.4,
  • protein phosphatase 1, regulatory subunit 83
  • identifiers:
  • 5610,
  • ENSG00000055332,
  • EIF2AK2

Genome feature

Region: gene ? Length: 57856  
Location: 2:37099210-37157065 reverse strand Cyto location: 2p22.2


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

18 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results