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Gene : BCCIP Homo sapiens

Name  ? BRCA2 and CDKN1A interacting protein Cytological Location  10q26.2
Brief Description  BRCA2 and CDKN1A interacting protein
Description  This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • TOK1,
  • TOK-1,
  • NM_016567,
  • BCCIP,
  • TOK-1,
  • OTTHUMG00000019237,
  • AB040451,
  • BRCA2 and CDKN1A-interacting protein,
  • HGNC:978,
  • uc001ljb.5,
  • BCCIPalpha
  • identifiers:
  • 56647,
  • ENSG00000107949,
  • BCCIP

Genome feature

Region: gene ? Length: 30150  
Location: 10:125823546-125853695 Cyto location: 10q26.2


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

929 SN Ps

5 Cross References

14 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results