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Gene : AICDA Homo sapiens

Name  ? activation induced cytidine deaminase Cytological Location  12p13.31
Brief Description  activation induced cytidine deaminase
Description  This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. AICDA is specifically expressed and active in germinal center-like B cells. In the germinal center, AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. An epigenetic role in neoplastic transformation and lymphoma progression has been experimentally ascribed to AICDA using mouse models. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Jul 2020]
  • synonyms:
  • OTTHUMG00000168676,
  • HIGM2,
  • uc001qur.3,
  • AB040430,
  • NM_020661,
  • HIGM2,
  • CDA2,
  • HEL-S-284,
  • AICDA,
  • CDA2,
  • HGNC:13203,
  • AID,
  • activation-induced cytidine deaminase,
  • AID,
  • ARP2,
  • ARP2
  • identifiers:
  • 57379,
  • ENSG00000111732,
  • AICDA

Genome feature

Region: gene ? Length: 10801  
Location: 12:8602170-8612970 reverse strand Cyto location: 12p13.31


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

1 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

113 SN Ps

5 Cross References

18 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results