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Gene : CCND1 Homo sapiens

Name  ? cyclin D1 Cytological Location  11q13.3
Brief Description  cyclin D1
Description  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
  • synonyms:
  • U21B31,
  • BCL1,
  • G1/S-specific cyclin D1,
  • PRAD1,
  • Z23022,
  • OTTHUMG00000167877,
  • PRAD1,
  • D11S287E,
  • CCND1,
  • U21B31,
  • D11S287E,
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1),
  • uc001opa.4,
  • NM_053056,
  • HGNC:1582,
  • BCL1,
  • parathyroid adenomatosis 1,
  • B-cell CLL/lymphoma 1
  • identifiers:
  • 595,
  • ENSG00000110092,
  • CCND1

Genome feature

Region: gene ? Length: 13319  
Location: 11:69641156-69654474 Cyto location: 11q13.3

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45 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Chromosomal location.

Gene --> GO terms.

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Gene --> Proteins.


Gene Report --> GWAS hit


3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



45 Pathways

188 SNPs

5 Cross References

19 Data Sets

7 Homologues

1 Located Features

97 Rna Seq Results