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Gene : CCND1 Homo sapiens

Name  ? cyclin D1 Cytological Location  11q13.3
Brief Description  cyclin D1
Description  The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]
  • synonyms:
  • CCND1,
  • U21B31,
  • NM_053056,
  • G1/S-specific cyclin D1,
  • uc001opa.4,
  • B-cell CLL/lymphoma 1,
  • PRAD1,
  • parathyroid adenomatosis 1,
  • Z23022,
  • cyclin D1 (PRAD1: parathyroid adenomatosis 1),
  • BCL1,
  • OTTHUMG00000167877,
  • PRAD1,
  • D11S287E,
  • HGNC:1582,
  • BCL1,
  • U21B31,
  • D11S287E
  • identifiers:
  • 595,
  • ENSG00000110092,
  • CCND1

Genome feature

Region: gene ? Length: 13319  
Location: 11:69641156-69654474 Cyto location: 11q13.3


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Function

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60 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

3 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

60 Pathways

188 SN Ps

5 Cross References

20 Data Sets

7 Homologues

1 Located Features

97 Rna Seq Results