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Gene : BCL2A1 Homo sapiens

Name  ? BCL2 related protein A1 Cytological Location  15q25.1
Brief Description  BCL2 related protein A1
Description  This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • synonyms:
  • HBPA1,
  • OTTHUMG00000144173,
  • ACC-1,
  • BCL2A1,
  • ACC-1,
  • BCL2L5,
  • GRS,
  • ACC1,
  • ACC-2,
  • ACC1,
  • BFL1,
  • ACC2,
  • HGNC:991,
  • HBPA1,
  • ACC2,
  • ACC-2,
  • BCL2L5,
  • NM_004049,
  • GRS,
  • uc002bfc.5,
  • BFL1
  • identifiers:
  • 597,
  • ENSG00000140379,
  • BCL2A1

Genome feature

Region: gene ? Length: 10305  
Location: 15:79960892-79971196 reverse strand Cyto location: 15q25.1


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0 Pathways

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Gene -> HPO annotation (Human Phenotype Ontology)

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Proteins

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SNPs

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Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

Gene(s) --> Significant SNPs (GTex data)

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Other

0 Pathways

21 SN Ps

5 Cross References

15 Data Sets

14 Homologues

0 Located Features

97 Rna Seq Results