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Gene : BCL2L2 Homo sapiens

Name  ? BCL2 like 2 Cytological Location  14q11.2
Brief Description  BCL2 like 2
Description  This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
  • synonyms:
  • BCL2-L-2,
  • BCL-W,
  • PPP1R51,
  • HGNC:995,
  • D87461,
  • uc001wjg.4,
  • protein phosphatase 1, regulatory subunit 51,
  • BCL-W,
  • BCLW,
  • PPP1R51,
  • OTTHUMG00000028738,
  • NM_004050,
  • KIAA0271,
  • BCL2L2
  • identifiers:
  • 599,
  • ENSG00000129473,
  • BCL2L2

Genome feature

Region: gene ? Length: 4998  
Location: 14:23306762-23311759 Cyto location: 14q11.2


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Function

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0 Pathways

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Gene --> Orthologues

Interactions

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Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

0 Pathways

205 SN Ps

5 Cross References

14 Data Sets

0 Homologues

0 Located Features

97 Rna Seq Results