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Gene : GAS5 Homo sapiens

Name  ? growth arrest specific 5 Cytological Location  1q25.1
Brief Description  growth arrest specific 5
Description  This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
  • synonyms:
  • SNHG2,
  • NCRNA00030,
  • uc057nkb.1,
  • growth arrest specific 5 (non-protein coding),
  • non-protein coding RNA 30,
  • NR_002578,
  • small nucleolar RNA host gene (non-protein coding) 2,
  • SNHG2,
  • BC038733,
  • GAS5,
  • OTTHUMG00000037216,
  • HGNC:16355,
  • NCRNA00030
  • identifiers:
  • 60674,
  • ENSG00000234741,
  • GAS5

Genome feature

Region: gene ? Length: 4984  
Location: 1:173863899-173868882 reverse strand Cyto location: 1q25.1


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0 Pathways

Gene --> GO terms.

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Disease

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0 Pathways

3753 SN Ps

5 Cross References

10 Data Sets

0 Homologues

0 Located Features

54 Rna Seq Results