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Gene : BGLAP Homo sapiens

Name  ? bone gamma-carboxyglutamate protein Cytological Location  1q22
Brief Description  bone gamma-carboxyglutamate protein
Description  This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
  • synonyms:
  • OTTHUMG00000014819,
  • OCN,
  • bone gamma-carboxyglutamate (gla) protein,
  • OCN,
  • BGLAP,
  • bone gla protein,
  • osteocalcin,
  • HGNC:1043,
  • BGP,
  • NM_199173,
  • X04143,
  • uc001fnt.4,
  • OC
  • identifiers:
  • 632,
  • ENSG00000242252,

Genome feature

Region: gene ? Length: 1134  
Location: 1:156242184-156243317 Cyto location: 1q22

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Gene -> HPO annotation (Human Phenotype Ontology)

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



3756 SN Ps

5 Cross References

14 Data Sets

6 Homologues

0 Located Features

97 Rna Seq Results