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Gene : CCL5 Homo sapiens

Name  ? C-C motif chemokine ligand 5 Cytological Location  17q12
Brief Description  C-C motif chemokine ligand 5
Description  This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]
  • synonyms:
  • TCP228,
  • MGC17164,
  • uc060eeh.1,
  • T-cell specific RANTES protein,
  • SCYA5,
  • small inducible cytokine A5 (RANTES),
  • eoCP,
  • chemokine (C-C motif) ligand 5,
  • SIS-delta,
  • SCYA5,
  • NM_002985,
  • HGNC:10632,
  • AF043341,
  • SIS-delta,
  • D17S136E,
  • TCP228,
  • small inducible cytokine subfamily A (Cys-Cys), member 5,
  • beta-chemokine RANTES,
  • regulated upon activation, normally T-expressed, and presumably secreted,
  • SISd,
  • D17S136E,
  • OTTHUMG00000188396,
  • T-cell specific protein p288,
  • SISd,
  • CCL5
  • identifiers:
  • 6352,
  • ENSG00000271503,
  • CCL5

Genome feature

Region: gene ? Length: 8870  
Location: 17:35871491-35880360 reverse strand Cyto location: 17q12

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0 Diseases

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184 SN Ps

5 Cross References

14 Data Sets

12 Homologues

3 Located Features

97 Rna Seq Results