help  | about  | cite  | software

Gene : CX3CL1 Homo sapiens

Name  ? C-X3-C motif chemokine ligand 1 Cytological Location  16q21
Brief Description  C-X3-C motif chemokine ligand 1
Description  This gene belongs to the CX3C subgroup of chemokines, characterized by the number of amino acids located between the conserved cysteine residues. This is the only member of the CX3C subgroup, which contains three amino acids between cysteine residues, resulting in a Cys-X-X-X-Cys configuration. The encoded protein contains an extended mucin-like stalk with a chemokine domain on top, and exists in both a membrane-anchored form where it acts as a binding molecule, or, in soluble form, as a chemotactic cytokine. The mature form of this protein can be cleaved at the cell surface, yielding different soluble forms that can interact with the G-protein coupled receptor, C-X3-C motif chemokine receptor 1 gene product. This gene plays a role in a wide range of diseases, including cancer, vasculitis, neuropathies, atherosclerosis, inflammatory diseases, and in human immunodeficiency virus infections. [provided by RefSeq, Sep 2017]
  • synonyms:
  • ABCD-3,
  • SCYD1,
  • fractalkine,
  • NTN,
  • NM_002996,
  • ABCD-3,
  • SCYD1,
  • OTTHUMG00000133469,
  • CXC3,
  • chemokine (C-X3-C motif) ligand 1,
  • NTN,
  • fractalkine,
  • C3Xkine,
  • CXC3C,
  • U84487,
  • neurotactin,
  • neurotactin,
  • CXC3,
  • CX3CL1,
  • NTT,
  • small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin),
  • C3Xkine,
  • HGNC:10647,
  • uc002eli.4,
  • CXC3C
  • identifiers:
  • 6376,
  • ENSG00000006210,
  • CX3CL1

Genome feature

Region: gene ? Length: 12555  
Location: 16:57372490-57385044 Cyto location: 16q21

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



71 SN Ps

5 Cross References

17 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results