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Gene : CRLF2 Homo sapiens

Name  ? cytokine receptor like factor 2 Cytological Location  X;Y
Brief Description  cytokine receptor like factor 2
Description  This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
  • synonyms:
  • CRL2,
  • CRLF2Y,
  • uc065cmw.1,
  • NM_022148,
  • OTTHUMG00000067432,
  • AF142570,
  • TSLPR,
  • CRLF2,
  • CRL2,
  • HGNC:14281,
  • identifiers:
  • 64109,
  • ENSG00000205755,
  • CRLF2

Genome feature

Region: gene ? Length: 22326  
Location: X:1190437-1212762 reverse strand Cyto location: X;Y

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



25 SNPs

5 Cross References

12 Data Sets

4 Homologues

0 Located Features

151 Rna Seq Results