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Gene : BMP4 Homo sapiens

Name  ? bone morphogenetic protein 4 Cytological Location  14q22.2
Brief Description  bone morphogenetic protein 4
Description  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016]
  • synonyms:
  • uc001xan.6,
  • BMP4,
  • AF035427,
  • MCOPS6,
  • BMP2B,
  • HGNC:1071,
  • NM_001202,
  • OFC11,
  • BMP2B,
  • BMP2B1,
  • OTTHUMG00000140303,
  • ZYME
  • identifiers:
  • 652,
  • ENSG00000125378,
  • BMP4

Genome feature

Region: gene ? Length: 7156  
Location: 14:53949736-53956891 reverse strand Cyto location: 14q22.2

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Gene -> HPO annotation (Human Phenotype Ontology)

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2 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



330 SNPs

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results