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Gene : BMP8B Homo sapiens

Name  ? bone morphogenetic protein 8b Cytological Location  1p34.2
Brief Description  bone morphogenetic protein 8b
Description  This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]
  • synonyms:
  • OTTHUMG00000009247,
  • BMP8,
  • BC023526,
  • bone morphogenetic protein 8 (osteogenic protein 2),
  • BMP8B,
  • OP-2,
  • uc001cdz.2,
  • BMP8,
  • HGNC:1075,
  • osteogenic protein 2,
  • NM_001720,
  • OP2
  • identifiers:
  • 656,
  • ENSG00000116985,
  • BMP8B

Genome feature

Region: gene ? Length: 31684  
Location: 1:39757182-39788865 reverse strand Cyto location: 1p34.2


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Function

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Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

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Gene --> Chromosomal location.

Gene --> GO terms.

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Interactions

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Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

3753 SN Ps

5 Cross References

16 Data Sets

10 Homologues

0 Located Features

97 Rna Seq Results