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Gene : BRAF Homo sapiens

Name  ? B-Raf proto-oncogene, serine/threonine kinase Cytological Location  7q34
Brief Description  B-Raf proto-oncogene, serine/threonine kinase
Description  This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017]
  • synonyms:
  • NM_004333,
  • M95712,
  • OTTHUMG00000157457,
  • v-raf murine sarcoma viral oncogene homolog B,
  • uc003vwc.5,
  • B-RAF1,
  • HGNC:1097,
  • RAFB1,
  • BRAF1,
  • BRAF,
  • NS7,
  • BRAF1,
  • B-raf
  • identifiers:
  • 673,
  • ENSG00000157764,
  • BRAF

Genome feature

Region: gene ? Length: 211602  
Location: 7:140713328-140924929 reverse strand Cyto location: 7q34


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Function

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Gene -> HPO annotation (Human Phenotype Ontology)

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Genomics

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Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

5 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

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Expression

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Other

262 SNPs

5 Cross References

19 Data Sets

3 Homologues

0 Located Features

97 Rna Seq Results