help  | about  | cite  | software

Gene : BRCA2 Homo sapiens

Name  ? BRCA2 DNA repair associated Cytological Location  13q13.1
Brief Description  BRCA2 DNA repair associated
Description  Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]
  • synonyms:
  • OTTHUMG00000017411,
  • FANCD1,
  • HGNC:1101,
  • FACD,
  • GLM3,
  • FAD,
  • FANCD,
  • XRCC11,
  • FANCD1,
  • breast cancer 2, early onset,
  • BRCA1/BRCA2-containing complex, subunit 2,
  • BRCA2,
  • uc001uub.2,
  • breast cancer 2,
  • BROVCA2,
  • XRCC11,
  • BRCC2,
  • Fanconi anemia, complementation group D1,
  • BRCC2,
  • FAD,
  • FACD,
  • FAD1,
  • U43746,
  • FAD1,
  • FANCD,
  • NM_000059,
  • PNCA2
  • identifiers:
  • 675,
  • ENSG00000139618,
  • BRCA2

Genome feature

Region: gene ? Length: 84761  
Location: 13:32315508-32400268 Cyto location: 13q13.1

Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer


Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.


Gene --> Proteins.


Gene Report --> GWAS hit


8 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


Homologue Displayer


Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions


Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.



774 SNPs

5 Cross References

19 Data Sets

3 Homologues

1 Located Features

97 Rna Seq Results