help  | about  | cite  | software

Gene : BRCA2 Homo sapiens

Name  ? BRCA2 DNA repair associated Cytological Location  13q13.1
Brief Description  BRCA2 DNA repair associated
Description  Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • synonyms:
  • HGNC:1101,
  • breast cancer 2, early onset,
  • FANCD,
  • FANCD1,
  • FAD1,
  • BRCC2,
  • BRCC2,
  • BRCA2,
  • XRCC11,
  • U43746,
  • XRCC11,
  • FANCD1,
  • Fanconi anemia, complementation group D1,
  • GLM3,
  • PNCA2,
  • FANCD,
  • breast cancer 2,
  • NM_000059,
  • BRCA1/BRCA2-containing complex, subunit 2,
  • FAD,
  • FAD1,
  • FACD,
  • FAD,
  • BROVCA2,
  • FACD,
  • OTTHUMG00000017411,
  • uc001uub.2
  • identifiers:
  • 675,
  • ENSG00000139618,
  • BRCA2

Genome feature

Region: gene ? Length: 84193  
Location: 13:32315480-32399672 Cyto location: 13q13.1


Uni Prot Comments Displayer

Protein Atlas Displayer

Gene Expression Atlas Tissues Displayer

Gene Expression Atlas Diseases Displayer

Publication Counts Displayer

Curated Proteins Displayer

Function

Gene Ontology Displayer

Gene --> GO terms.

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Genomics

J Browse Displayer

Gene Structure Displayer

Overlapping Features Displayer

Mouse Alleles Displayer

Gene --> Chromosomal location.

Gene --> GO terms.

Gene --> Overlapping genes.

Proteins

Gene --> Proteins.

SNPs

Gene Report --> GWAS hit

Disease

8 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

Gene --> Alleles and Disease (clinVar data)

Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]

Homology

Homologue Displayer

Gene --> Orthologues

Interactions

Cytoscape Network Displayer

Gene --> Physical and Genetic Interactions

Expression

Gene(s) --> Significant SNPs (GTex data)

Gene Ontology

Gene --> GO terms.

 

Other

774 SN Ps

5 Cross References

20 Data Sets

4 Homologues

1 Located Features

97 Rna Seq Results