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Gene : ELOC Homo sapiens

Name  ? elongin C Cytological Location  8q21.11
Brief Description  elongin C
Description  This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
  • synonyms:
  • OTTHUMG00000164501,
  • SIII,
  • TCEB1,
  • transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C),
  • transcription elongation factor B subunit 1,
  • transcription elongation factor B (SIII), polypeptide 1 (15kD, elongin C),
  • HGNC:11617,
  • SIII,
  • L34587,
  • ELOC,
  • TCEB1,
  • uc003yaa.3,
  • NM_005648
  • identifiers:
  • 6921,
  • ENSG00000154582,
  • ELOC

Genome feature

Region: gene ? Length: 27169  
Location: 8:73945119-73972287 reverse strand Cyto location: 8q21.11

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43 Pathways

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0 Diseases

Gene (Hum OR Rat) --> Mouse Allele (Phenotype)

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Gene -> HPO annotation (Human Phenotype Ontology)

Mouse Gene --> Allele [Phenotype]


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43 Pathways

145 SN Ps

5 Cross References

17 Data Sets

11 Homologues

0 Located Features

97 Rna Seq Results