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Gene : ELOB Homo sapiens

Name  ? elongin B Cytological Location  16p13.3
Brief Description  elongin B
Description  This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, Aug 2008]
  • synonyms:
  • L42856,
  • transcription elongation factor B subunit 2,
  • uc002crn.4,
  • TCEB2,
  • SIII,
  • NM_007108,
  • TCEB2,
  • SIII,
  • HGNC:11619,
  • transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B),
  • OTTHUMG00000154125,
  • ELOB
  • identifiers:
  • 6923,
  • ENSG00000103363,
  • ELOB

Genome feature

Region: gene ? Length: 5867  
Location: 16:2771414-2777280 reverse strand Cyto location: 16p13.3


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43 Pathways

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43 Pathways

12 SN Ps

5 Cross References

17 Data Sets

12 Homologues

0 Located Features

97 Rna Seq Results